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In mammals, the skin is an organ of the integumentary system made up of multiple layers of ectodermal tissue, and guards the underlying muscles, bones, ligaments and internal organs.Skin of a different nature exists in amphibians, reptiles, and birds.Amphibian skin plays key roles in everyday survival and their ability to exploit a wide range of habitats and ecological conditions.(See also: image rotating (1.1 mb)) Optical coherence tomogram of fingertip, depicting stratum corneum (~500 µm thick) with stratum disjunctum on top and stratum lucidum (connection to stratum spinosum) in the middle. It forms a protective barrier over the body's surface, responsible for keeping water in the body and preventing pathogens from entering, and is a stratified squamous epithelium, Keratinocytes in the stratum basale proliferate through mitosis and the daughter cells move up the strata changing shape and composition as they undergo multiple stages of cell differentiation to eventually become anucleated.
It harbors many mechanoreceptors (nerve endings) that provide the sense of touch and heat through nociceptors and thermoreceptors.
The epidermis and dermis are separated by a thin sheet of fibers called the basement membrane, which is made through the action of both tissues.
The basement membrane controls the traffic of the cells and molecules between the dermis and epidermis but also serves, through the binding of a variety of cytokines and growth factors, as a reservoir for their controlled release during physiological remodeling or repair processes.
It also contains the hair follicles, sweat glands, sebaceous glands, apocrine glands, lymphatic vessels and blood vessels.
The blood vessels in the dermis provide nourishment and waste removal from its own cells as well as for the epidermis.It consists of loose connective tissue and elastin.